Flushing; frequent diarrhea (> 4 loose stools/day); wheezing; telangiecstasia (facial red spots); chronic abdominal cramping, pain and bloating; joint pain; fatigue.

The incidents of NETs is 3.6/100,000 persons. It actually occurs as frequently as testicular cancer, Hodgkin's Disease, gliomas (brain tumors) and multiple myeloma. (Modlin, et al, 2013) - The general professional consensus is that because NETs presents as so many other health disorders, and as such, causes misdiagnosis, the disease may not be as rare as previously thought.

While some types of tumors have been evidenced not to metastasize, those are the exception to the rule. Predominantly there is no known cure for NETs.

Yes, please contact Mark Kidd, PhD, DABCC (mkidd@wrenlaboratories.com or 203-208-3464) for more information.

It is of utmost importance that you partner with a NETs specialist in the management of your disease. When the primary is unknown, the focus of treatment(s) turn toward the metastatic disease. Therapies are then decided based on the site of metastasis; the clinical symptoms; the tumor burden (amount of tumor) as well as the staging, differentiation and activity of the metastatic disease.

There have been cases of surgical removal of a Neuroendocrine Tumor (NET) tumor without further occurrence of the disease (i.e. appendix; ovary), however, it is very difficult for the surgeon to obtain "clear margins" when excising NETs as the disease usually remains present in the organ tissues at a molecular level.

Please visit our Resource Library for the most current literature.

Yes, please contact Mark Kidd, PhD, DABCC (mkidd@wrenlaboratories.com or 203-208-3464) for more information.

To order a test, please go to www.wrenlaboratories.com and click on the “Order a NETest” button. This will take you to a landing page. Please click on the “North American practitioners Click Here” button. This will take you to a page that will ask you to provide some details. Please fill in all fields including details for you and for your patient. It is very important to identify whether a kit will be sent to your office address or to the patient’s home address. Please ensure the correct button is clicked. There is also “CAPTCHA” icon at the bottom. Please fill this in and submit. This activates your test order. We will send you or your patient a kit (to the address you provided on registration).

To order a test, you first need to register on the website. Please go to www.wrenlaboratories.com and click on the “Order a NETest” button. This will take you to a registration page. Please fill in your details including your address, to which the kit will be sent. Your email will be your login name. You will be asked to provide your own password. Please save both as these are user specific and are required for ordering the test. After you have set-up your account you will receive a registration confirmation email from us within 24-72 hrs. This will include a specific password (a mixture of numbers and letters) that we will provide you. You will need this password to open the patient reports. Once you have received confirmation you can order the test.

At www.wrenlaboratories.com enter the ordering site and login using your email and the password you chose at registration. This will open a page with options for ordering the NETest or the PPQ/PRRedicTor test. Chose the test and follow the instructions regarding patient information and payment. Please fill in all the required patient information. This is essential for the generation of an accurate test report. Once you have finished ordering the test online, we will email you a requisition form with your order as a .pdf. Please print out the order form which will include the test ordered, your details and the patient’s information. This form needs to be signed by you and included with the patient sample. It has a bar code (top right) that links the order to the sample and patient’s details. We will send you a kit (to the address you provided on registration) with the blood collection tube and instructions for collecting the blood sample and sending it to the laboratory for analysis. If you require tracking information for the kit, please request this directly from us and we will provide it.

Yes, once you have finished ordering the NETest, you can then add the PPQ/PRRedicTor test. Please ensure the tumour grade is included when you order the PPQ. We will send you a separate email with a requisition form for the PPQ. Please note, you only need to collect one blood tube for both the NETest and PPQ test.

Each kit includes a blood collection tube, instructions for collecting the blood sample, a requisition form that the physician will need to fill in and sign, a brief patient history form that needs completion, as well as instructions regarding sending it to the laboratory for analysis. If you require tracking information for the kit, please request this directly from us and we will provide it.

The instructions for collection are provided with the kit and can also be found here. At least 2 ml of blood should be drawn into the provided tube. Please include the appropriate patient identifiers on the tube. Once the collection is complete, either send the sample within 24 hours or freeze the sample at -80°C (NOT a normal refrigerator freezer) until send-out. Please send the sample on the same or on next day to the laboratory using the kit provided. Shipping is at ambient temperature. NO DRY ICE IS NEEDED. Please remember to include the order form that you signed in the kit.

If you are conducting a study and are collecting several patient samples over a period of time and want to batch send the samples in one delivery, please freeze all collected tubes in a -80°C freezer (NOT a normal refrigerator freezer). Samples should be frozen within 24 hrs of collection. Once sufficient samples are collected (e.g., 20), please send to the laboratory by courier at ambient temperature using the kit box provided.

Please click here to download the collection protocol.

If you have misplaced the instructions for collection click here. If you have misplaced the kit or requisition forms please contact us.

Each kit includes a pre-paid FEDEX label and a white polystyrene box.

Please ensure the blood sample is placed into the box.

Please include the box containing the blood sample tube, a fully completed and signed requisition form and the brief patient history form.

‍Please include any relevant clinical notes related to ordering the test (physician notes/clinical history).

Please call FEDEX, and they will send someone to your office to pick up the kit.

Feedback can be done via phone, email or on GOOGLE reviews. To access GOOGLE reviews, you will need a gmail account.